Virtualbox's mouse integration doesn't work with most games. In VMware, the game quickly succumbed to an error that caused incorrect colors to be displayed.

I was able to get through the entire Starcraft shareware campaign in Virtualbox with no issue. Neither program provides much support for scaling up a 640x480 program (Like MOO2, Diablo, or Starcraft) to occupy a 1024x768 region on a 1366x768 screen. In Virtualbox, by contrast, Quake 2 and Elite Force are 100% fine, and Far Cry just has render distance issues (namely anything farther away than two inches from your face gets rendered as solid gray). Quake 2, Star Trek Voyager: Elite Force, and Far Cry all have mouse control issues in VMware that make them effectively unplayable. VMware runs them with flawless sound but worse frame rates. Doom 3 and Quake 4 have better frame rates in Virtualbox, but frequent sound glitches/stuttering. Lithtech Engine games run better in VMware AvP2 doesn't run at all in Virtualbox

VMware has buggier support for animated wallpapers (Windows Active Desktop)

VMware is better at running old versions of Windows, but Virtualbox is better at running ON older versions of Windows (VMware 16 won't run on anything older than Win10) I haven't yet tried to create a multiboot VM with Virtualbox but I expect it to be possible. VMware Workstation Player does not allow setting the boot order, making it difficult or impossible to create a multiboot virtual machine (though I have no idea why you'd want to do this).

Virtualbox vs vmware ui